Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA. This loop is important for anchoring elongation factor (EF-G for prokaryote or eEF2 for eukaryote) in mRNA translocation. Tran...

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Bibliographic Details
Main Authors: Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng, Pang-Chui Shaw
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Toxins
Subjects:
ribosome inactivating protein
therapeutic applications
immunotoxin
anti-hiv
anti-cancer
Online Access:https://www.mdpi.com/2072-6651/12/3/167

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