Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway

Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway

Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically del...

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Bibliographic Details
Main Authors: Andrea Mencarelli, Maurizio Vacca, Hanif Javanmard Khameneh, Enzo Acerbi, Alicia Tay, Francesca Zolezzi, Michael Poidinger, Alessandra Mortellaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
calcineurin B
nuclear factor of activated T cell
colitis
CD4+ T cells
inflammatory bowel disease
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00261/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00261/full

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