Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway

Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway

We investigated long-lasting changes in endothelial and vascular function in adult rat survivors of severe sepsis induced by cecal ligation and puncture (CLP) model. For this, male Wistar rats (200–350 g) had their cecum punctured once (non-transfixing hole) with a 14-gauge needle. Performed in this...

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Bibliographic Details
Main Authors:	Priscila de Souza, Karla Lorena Guarido, Karin Scheschowitsch, Luísa Mota da Silva, Maria Fernanda Werner, Jamil Assreuy, José Eduardo da Silva-Santos
Format:	Article
Language:	English
Published:	Elsevier 2016-12-01
Series:	Redox Biology
Subjects:	Vascular tone Calcium sensitization NAD(P)H oxidase Septic shock
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231716301409

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