Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression.

Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression.

SRY is a sex-determining gene that encodes a transcription factor, which triggers male development in most mammals. The molecular mechanism of SRY action in testis determination is, however, poorly understood. In this study, we demonstrate that WDR5, which encodes a WD-40 repeat protein, is a direct...

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Bibliographic Details
Main Authors: Zhen Xu, Xinxing Gao, Yinghong He, Junyi Ju, Miaomiao Zhang, Ronghua Liu, Yupeng Wu, Chunyan Ma, Chi Ma, Zhaoyu Lin, Xingxu Huang, Quan Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3327683?pdf=render

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