The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

Multiple myeloma (MM) is well-known for the development of drug resistance, leading to relapse. Therefore, finding novel treatment strategies remains necessary. By performing a lipidomics assay on MM patient plasma, we aimed to identify new targets. We observed a dysregulation in the sphingolipid me...

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Bibliographic Details
Main Authors: Sylvia Faict, Inge Oudaert, Ludovic D’Auria, Jonas Dehairs, Ken Maes, Philip Vlummens, Kim De Veirman, Elke De Bruyne, Karel Fostier, Isabelle Vande Broek, Rik Schots, Karin Vanderkerken, Johannes V. Swinnen, Eline Menu
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
lipidomics
drug resistance
exosomes
extracellular vesicles
multiple myeloma
Online Access:https://www.mdpi.com/2072-6694/11/12/1823

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