| Summary: | <p class="pre" style="text-align: justify; text-justify: inter-ideograph; background: #f8f9fa;" align="justify"><strong><span style="font-family: 'Times New Roman';">Background.</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> Earlier in clinical observations </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">four variants of the immune responses to adaptogenic balneotherapy at the </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">Truskavets’ spa</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> have been identified. In 40,9% of patients, initially normal immune status did not change significantly; in 31,8%, the lower boundary level of immunity is completely normalized; in 22,7% moderate immunosuppression is reduced, but not up to normal; however, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. All four variants of immune responses are virtually unmistakably predicted by a set of 20 predictors. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">The </span><strong><span style="font-family: 'Times New Roman';">purpose</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> of this study is to analyze vegetative, endocrine and metabolic accompaniments of individual immune responses to balneofactors of Truskavets’ spa. </span><strong><span style="font-family: 'Times New Roman';">Material and methods. </span></strong><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">The</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">object</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">of</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">observation</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">were</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> 34</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">men</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">and</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> 10 </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">women</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">aged</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">24-70</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">years</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">old</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">,</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">who</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">came</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">to</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">the</span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">Truskavets</span><span class="16" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">’ </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">spa</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> for the treatment </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">of chronic pyelonephritis combined with</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">cholecystitis in</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="17" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">remission</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #212121; font-size: 12,0000pt;">The survey was conducted twice, before and after balneotherapy (</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">drinking bioactive water Naftussya three times a day, ozokerite applications, mineral baths every other day for 7-10 days</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">)</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #212121; font-size: 12,0000pt;">. </span><span class="15" style="font-family: 'Times New Roman';">Immune status evaluated on a set of I and II levels recommended by the WHO.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">The state of the autonomic nervous system is estimated by HRV</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> (</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">"CardioLab+HRV"</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">)</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">. To assess endocrine status</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">we determined plasma levels of </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">principal adaptation Hormones</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">: Cortisol, Testosterone and Triiodothyronine (ELISA).</span><span class="15" style="font-family: 'Times New Roman';"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">We determined also the plasma and daily urine levels of the electrolytes: calcium, phosphates, sodium, potassium, magnesium and chloride as well as nitrous metabolites creatinine, urea and uric acid. According to the parameters of electrolyte exchange, parathyroid, calcitonin and mineralocorticoid hormonal activities was evaluated. We estimated also plasma lipide spectrum.</span><strong><span style="font-family: 'Times New Roman';"> Results.</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">13 immunosuppressive and 6 immune-enhancing neuro-endocrine and metabolic parameters identified. Discriminant analysis conducted to identify parameters, in which the four immune response clusters differ significantly from each other. 25 parameters are characteristic, </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">12</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;"> of them related to the</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> HRV, 5 to endocrine, 5 to electrolytes and 3 to nitrous metabolites exchange. </span><strong><span style="font-family: 'Times New Roman';">Conclusion</span></strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; color: #222222; font-size: 12,0000pt;">Individual immune responses to adaptogenic balneofactors are accompanied by characteristic changes in the parameters of the autonomic nervous and endocrine systems, as well as the exchange of electrolytes, nitrogen metabolites and lipids.</span></p>
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