The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation

The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation

Objective. Previous studies have characterized the hepatoprotective and anti-inflammatory properties of oleanolic acid (OA). This study aimed to investigate the molecular mechanisms of OA hepatoprotection in concanavalin A- (ConA-) induced acute liver injury. Materials and Methods. ConA (20 mg/kg) w...

Full description

Bibliographic Details
Main Authors:	Wenwen Wang, Kan Chen, Yujing Xia, Wenhui Mo, Fan Wang, Weiqi Dai, Peiqin Niu
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	PPAR Research
Online Access:	http://dx.doi.org/10.1155/2018/3180396

Similar Items

Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo
by: Fuhao Chu, et al.
Published: (2018-02-01)

Oleanolic Acid Enhances the Beneficial Effects of Preconditioning on PC12 Cells
by: Babongile C. Ndlovu, et al.
Published: (2014-01-01)

Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy
by: Wenwen Wang, et al.
Published: (2019-01-01)

Polydatin exhibits the hepatoprotective effects through PPAR-α/-β signaling pathway in Streptozocin-induced diabetic mice
by: Lai Xue, et al.
Published: (2017-09-01)

Oleanolic acid ethanol monosolvate
by: Anna Froelich, et al.
Published: (2010-11-01)

Recent advances in nanoparticle formulation of oleanolic acid
by: Wang Shengpeng, et al.
Published: (2011-05-01)

Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid
by: Xiaoxu Yang, et al.
Published: (2016-04-01)

Trypanocidal effect of betulinic and oleanolic acids
by: Paloma LeÃo de Sousa
Published: (2017)

Scaffold-based pan-agonist design for the PPARα, PPARβ and PPARγ receptors.
by: Li-Song Zhang, et al.
Published: (2012-01-01)

PPARα and PPARγ as main regulators of fatty acid metabolism
by: Mirosław Kucharski, et al.
Published: (2018-10-01)

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
by: Wang R, et al.
Published: (2018-05-01)

Facile Synthesis of Oleanolic Acid Monoglycosides and Diglycosides
by: Mao-Sheng Cheng, et al.
Published: (2008-07-01)

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update
by: Jéssica A. Jesus, et al.
Published: (2015-01-01)

Antiviral Activities of Oleanolic Acid and Its Analogues
by: Vuyolwethu Khwaza, et al.
Published: (2018-09-01)

Effect of oleanolic acid in activation of nuclear receptors
by: Chih-Ching Lin, et al.
Published: (2006)

Antibacterial activity of oleanolic and ursolic acids and their derivatives
by: Wolska Krystyna, et al.
Published: (2010-10-01)

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
by: Jiao Feng, et al.
Published: (2020-01-01)

Identification of Oleanolic Acid as Allosteric Agonist of Integrin αM by Combination of In Silico Modeling and In Vitro Analysis
by: Lu Jin, et al.
Published: (2021-09-01)

Synthesis and Anti-Fungal Activity of Seven Oleanolic Acid Glycosides
by: Daoquan Wang, et al.
Published: (2011-01-01)

Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents
by: Fuhao Chu, et al.
Published: (2014-11-01)

Hypoxia Imaging and Biological Evaluation of the Radiosensitizing Effect of Oleanolic Acid
by: Hui Wang, et al.
Published: (2018-01-01)

Microwave-Assisted Extraction of Oleanolic Acid and Ursolic Acid from Ligustrum lucidum Ait
by: Yang Song, et al.
Published: (2011-08-01)

PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL
by: R. V. Gostishchev, et al.
Published: (2017-10-01)

Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters
by: Xiaomei Liang, et al.
Published: (2013-03-01)

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway
by: Xiang S, et al.
Published: (2020-01-01)

Oleanolic acid ameliorates intestinal alterations associated with EAE
by: Beatriz Gutierrez, et al.
Published: (2020-11-01)

Simple amides of oleanolic acid as effective penetration enhancers.
by: Barbara Bednarczyk-Cwynar, et al.
Published: (2015-01-01)

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential
by: Evelina Gudoityte, et al.
Published: (2021-04-01)

PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists
by: Neerupma Silswal, et al.
Published: (2012-01-01)

Antiprotozoal Activity of Triazole Derivatives of Dehydroabietic Acid and Oleanolic Acid
by: Mariano Walter Pertino, et al.
Published: (2017-02-01)

Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity
by: Wenhui Mo, et al.
Published: (2018-01-01)

2D-QSAR Analysis of Oxadiazole Substituted α-Isopropoxy phenylpropionic Acids as PPAR-α & PPAR-λ Agonists
by: Soni L. K., et al.
Published: (2004-01-01)

Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns
by: Jie Huang, et al.
Published: (2016-05-01)

Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes
by: Xue Wang, et al.
Published: (2015-01-01)

An Ideal PPAR Response Element Bound to and Activated by PPARα.
by: John Tzeng, et al.
Published: (2015-01-01)

Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles
by: Xia X, et al.
Published: (2017-05-01)

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling
by: Qiang Yu, et al.
Published: (2018-01-01)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
by: Xu Wang, et al.
Published: (2017-09-01)

Free radical scavenging and α-glucosidase inhibition, two potential mechanisms involved in the anti-diabetic activity of oleanolic acid
by: J. M. Castellano, et al.
Published: (2016-09-01)

Oleanolic acid: its isolation and derivatisation to potential antimicrobial compounds
by: Wicht, Merrill Margaret
Published: (2012)