AVALIAÇÃO DA GAMA-GLUTAMILTRANSFERASE NA URINA DE CADELAS COM PIOMETRA
Female dogs with pyometra may present tubular injuries caused by deposition of immune complexes that promote the development of primary glomerular disease, interstitial tubular injury, azotemia and reductions in the capacity for urinary concentration in the renal tubules and in the capacity f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDUFU
2014-01-01
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| Series: | Veterinary News |
| Subjects: | |
| Online Access: | http://www.seer.ufu.br/index.php/vetnot/article/view/24616/14484 |
| Summary: | Female dogs with pyometra may present
tubular injuries caused by deposition of
immune complexes that promote the
development of primary glomerular
disease, interstitial tubular injury, azotemia
and reductions in the capacity for urinary
concentration in the renal tubules and in
the capacity for glomerular filtration.
Considering the importance of early
detection of renal tubule lesions in dogs
with uterine infection, this study aims to
determine the concentration of GGTu in
the urine of 23 dogs aged between three
and 13 years, diagnosed with pyometra.
We determined serum levels of urea and
creatinine and concentration of the
enzyme GGTu in urine, by the colorimetric
method, and the absorbance by
spectrophotometry in automatic apparatus.
The urinary density and presence of
urinary protein excretion were measured
using a urine reagent strip. Mean urinary
density was 1,015 and urinary protein
excretion was found in 65% (15/23) of
animals. Elevated levels of urea were
observed in all animals and of creatinine in
22% (5/23) of the animals studied, with the
mean values being equal to 60.39 mg/dL
and 1.38 mg/dL, respectively. Among the
dogs evaluated with pyometra, 43%
(10/23) showed an increase of GGTu, with
a mean of 180U/L. Elevated GGTu without
concomitant increase in serum creatinine
was observed in 70% of animals (7/10),
indicating that the measurement of the
activity of GGTu in urine is a more
appropriate laboratory test for the
detection of acute tubular injury in dogs
with pyometra than measuring urea and
creatinine in the serum, when trying to
detect the presence of tubular injury. |
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| ISSN: | 1983-0777 1983-0777 |