Unilateral RS3PE in a Patient of Seronegative Rheumatoid Arthritis

• Main Authors: Ankur Nandan Varshney, Nilesh Kumar, Ashutosh Tiwari, Ravi Anand, Sashi Ranjan Prasad, Arvind Anand, Abhinandan Mishra, N. K. Singh
• Format: Article
• Language: English
• Published: Hindawi Limited 2013-01-01
• Series: Case Reports in Rheumatology
• Online Access: http://dx.doi.org/10.1155/2013/923797

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare but well-reported clinical entity. It is classically described as symmetrical involvement of both upper extremities. Asymmetrical involvement had also been reported, but unilateral presentation is very rare. We hereby report a case of unilateral RS3PE in a patient of seronegative rheumatoid arthritis which was initially misdiagnosed as cellulitis and was given high dose antibiotics without any significant improvement. Later a rheumatologic consultation leads to a prompt diagnosis, and treatment with steroids leads to dramatic reversal of symptoms. This case demonstrates the rare presentation of this rare clinical entity and highlights the necessity of awareness regarding unilateral disease to clinicians.