Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives

Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives

Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines—namely HCT-116 (colorectal), the uterine sarcoma MES-SA, and its doxorubicin...

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Bibliographic Details
Main Authors: Maria Karelou, Vasileios Kourafalos, Athanasia P. Tragomalou, Panagiotis Marakos, Nicole Pouli, Ourania E. Tsitsilonis, Evangelos Gikas, Ioannis K. Kostakis
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
acridines
cancer
drug discovery
stability
computational chemistry
mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/25/19/4584

Internet

https://www.mdpi.com/1420-3049/25/19/4584

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