(11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione

(11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione

The title chiral compound, C13H14N2O4, was prepared by an intracyclization reaction of methyl (S)-1-(4-hydroxy-5-methoxy-2-nitrobenzyl)-5-oxopyrrolidine-2-carboxylate in the presence of ethanol and iron. The five-membered substituted pyrrole ring adopts an approximate envelope conformation, while th...

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Main Authors: Dong-Mei Zhao, Chao Ma, Yu Sha, Jing-Hong Liu, Mao-Sheng Cheng
Format: Article
Language:English
Published: International Union of Crystallography 2008-01-01
Series:Acta Crystallographica Section E
Online Access:http://scripts.iucr.org/cgi-bin/paper?S1600536807066056
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spelling doaj-81d6384be5a94e1dbdb74b991140aea22020-11-25T01:50:34ZengInternational Union of CrystallographyActa Crystallographica Section E1600-53682008-01-01641o266o26610.1107/S1600536807066056(11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dioneDong-Mei ZhaoChao MaYu ShaJing-Hong LiuMao-Sheng ChengThe title chiral compound, C13H14N2O4, was prepared by an intracyclization reaction of methyl (S)-1-(4-hydroxy-5-methoxy-2-nitrobenzyl)-5-oxopyrrolidine-2-carboxylate in the presence of ethanol and iron. The five-membered substituted pyrrole ring adopts an approximate envelope conformation, while the seven-membered substituted diazepine ring displays a twist-boat conformation. Intermolecular O—H...O and N—H...O hydrogen bonding helps to stabilize the crystal structure.http://scripts.iucr.org/cgi-bin/paper?S1600536807066056
collection DOAJ
language English
format Article
sources DOAJ
author Dong-Mei Zhao
Chao Ma
Yu Sha
Jing-Hong Liu
Mao-Sheng Cheng
spellingShingle Dong-Mei Zhao
Chao Ma
Yu Sha
Jing-Hong Liu
Mao-Sheng Cheng
(11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
Acta Crystallographica Section E
author_facet Dong-Mei Zhao
Chao Ma
Yu Sha
Jing-Hong Liu
Mao-Sheng Cheng
author_sort Dong-Mei Zhao
title (11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
title_short (11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
title_full (11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
title_fullStr (11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
title_full_unstemmed (11aS)-8-Hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
title_sort (11as)-8-hydroxy-7-methoxy-2,3,5,10,11,11a-hexahydro-1h-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
publisher International Union of Crystallography
series Acta Crystallographica Section E
issn 1600-5368
publishDate 2008-01-01
description The title chiral compound, C13H14N2O4, was prepared by an intracyclization reaction of methyl (S)-1-(4-hydroxy-5-methoxy-2-nitrobenzyl)-5-oxopyrrolidine-2-carboxylate in the presence of ethanol and iron. The five-membered substituted pyrrole ring adopts an approximate envelope conformation, while the seven-membered substituted diazepine ring displays a twist-boat conformation. Intermolecular O—H...O and N—H...O hydrogen bonding helps to stabilize the crystal structure.
url http://scripts.iucr.org/cgi-bin/paper?S1600536807066056
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AT maoshengcheng 11as8hydroxy7methoxy235101111ahexahydro1hpyrrolo21c14benzodiazepine311dione
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