Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions

Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions

Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a hydrazinolysis or hydrolysis reaction and subsequent hydr...

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Bibliographic Details
Main Authors: Angélica de Fátima S. Barreto, Veronica Alves dos Santos, Carlos Kleber Z. Andrade
Format: Article
Language:English
Published: Beilstein-Institut 2016-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acylhydrazino-peptomers
consecutive Ugi reactions
peptide-peptoid hybrid
peptomer
Online Access:https://doi.org/10.3762/bjoc.12.285

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