Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model

Abstract Background Cancer cachexia is a severe condition that leads to the death of advanced cancer patients, and approximately 50~80% of cancer patients have cancer cachexia. Ginseng extract has been reported to have substantial anticancer and immune-enhancing effects; however, no study has report...

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Main Authors: Shuai Lu, Yubo Zhang, Huajun Li, Jing Zhang, Yingqian Ci, Mei Han
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Online Access:https://doi.org/10.1186/s12906-019-2797-9
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spelling doaj-81d41a6ce62f4ea48d707599bb4bd56b2021-01-17T12:25:29ZengBMCBMC Complementary Medicine and Therapies2662-76712020-01-012011910.1186/s12906-019-2797-9Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse modelShuai Lu0Yubo Zhang1Huajun Li2Jing Zhang3Yingqian Ci4Mei Han5Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityAbstract Background Cancer cachexia is a severe condition that leads to the death of advanced cancer patients, and approximately 50~80% of cancer patients have cancer cachexia. Ginseng extract has been reported to have substantial anticancer and immune-enhancing effects; however, no study has reported the use of ginseng alone to treat cancer cachexia. Our study’s purpose was to investigate the therapeutic effects of ginseng-related monomers or mixtures on a cancer cachexia mouse model. Methods We selected BALB/c mice and injected the mice subcutaneously with C26 colon cancer cells to construct a cancer cachexia experimental animal model. The water extract of ginseng (WEG), two types of ginseng extracts (ginsenosides at doses of 5 mg/kg (GE5) and 50 mg/kg (GE50)) and ginsenoside Rb1 (Rb1) were used to treat cancer cachexia mice. Enzyme-linked immunosorbent assays (ELISAs) were used to analyze the inhibitory effects on two key inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Results Our experimental results show that GE5, GE50 and Rb1 significantly reduced the levels of TNF-α (P < 0.01) and IL-6 (P < 0.01), which are closely related to cancer cachexia; however, WEG, GE5, GE50 and Rb1 did not significantly improve the gastrocnemius muscle weight or the epididymal fat weight of mice with cancer cachexia. Conclusions These results indicate that GE5, GE50 and Rb1 may be useful for reducing symptoms due to inflammation by reducing the TNF-α and IL-6 cytokine levels in cancer cachexia mice, thereby ameliorating the symptoms of cancer cachexia. Our results may be beneficial for future studies on the use of Chinese herbal medicines to treat cancer cachexia.https://doi.org/10.1186/s12906-019-2797-9Cancer cachexiaMouse modelWater extract of ginsengGinseng extractGinsenoside Rb1TNF-α
collection DOAJ
language English
format Article
sources DOAJ
author Shuai Lu
Yubo Zhang
Huajun Li
Jing Zhang
Yingqian Ci
Mei Han
spellingShingle Shuai Lu
Yubo Zhang
Huajun Li
Jing Zhang
Yingqian Ci
Mei Han
Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model
BMC Complementary Medicine and Therapies
Cancer cachexia
Mouse model
Water extract of ginseng
Ginseng extract
Ginsenoside Rb1
TNF-α
author_facet Shuai Lu
Yubo Zhang
Huajun Li
Jing Zhang
Yingqian Ci
Mei Han
author_sort Shuai Lu
title Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model
title_short Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model
title_full Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model
title_fullStr Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model
title_full_unstemmed Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model
title_sort ginsenoside rb1 can ameliorate the key inflammatory cytokines tnf-α and il-6 in a cancer cachexia mouse model
publisher BMC
series BMC Complementary Medicine and Therapies
issn 2662-7671
publishDate 2020-01-01
description Abstract Background Cancer cachexia is a severe condition that leads to the death of advanced cancer patients, and approximately 50~80% of cancer patients have cancer cachexia. Ginseng extract has been reported to have substantial anticancer and immune-enhancing effects; however, no study has reported the use of ginseng alone to treat cancer cachexia. Our study’s purpose was to investigate the therapeutic effects of ginseng-related monomers or mixtures on a cancer cachexia mouse model. Methods We selected BALB/c mice and injected the mice subcutaneously with C26 colon cancer cells to construct a cancer cachexia experimental animal model. The water extract of ginseng (WEG), two types of ginseng extracts (ginsenosides at doses of 5 mg/kg (GE5) and 50 mg/kg (GE50)) and ginsenoside Rb1 (Rb1) were used to treat cancer cachexia mice. Enzyme-linked immunosorbent assays (ELISAs) were used to analyze the inhibitory effects on two key inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Results Our experimental results show that GE5, GE50 and Rb1 significantly reduced the levels of TNF-α (P < 0.01) and IL-6 (P < 0.01), which are closely related to cancer cachexia; however, WEG, GE5, GE50 and Rb1 did not significantly improve the gastrocnemius muscle weight or the epididymal fat weight of mice with cancer cachexia. Conclusions These results indicate that GE5, GE50 and Rb1 may be useful for reducing symptoms due to inflammation by reducing the TNF-α and IL-6 cytokine levels in cancer cachexia mice, thereby ameliorating the symptoms of cancer cachexia. Our results may be beneficial for future studies on the use of Chinese herbal medicines to treat cancer cachexia.
topic Cancer cachexia
Mouse model
Water extract of ginseng
Ginseng extract
Ginsenoside Rb1
TNF-α
url https://doi.org/10.1186/s12906-019-2797-9
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