A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique

A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique

Deep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating si...

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Main Authors: A. Paffi, F. Apollonio, M. G. Puxeddu, M. Parazzini, G. d’Inzeo, P. Ravazzani, M. Liberti
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/262739
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spelling doaj-81c8e5358be64af59e86c2d250565d912020-11-24T22:42:47ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/262739262739A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS TechniqueA. Paffi0F. Apollonio1M. G. Puxeddu2M. Parazzini3G. d’Inzeo4P. Ravazzani5M. Liberti6Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyItalian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyItalian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyDeep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.http://dx.doi.org/10.1155/2013/262739
collection DOAJ
language English
format Article
sources DOAJ
author A. Paffi
F. Apollonio
M. G. Puxeddu
M. Parazzini
G. d’Inzeo
P. Ravazzani
M. Liberti
spellingShingle A. Paffi
F. Apollonio
M. G. Puxeddu
M. Parazzini
G. d’Inzeo
P. Ravazzani
M. Liberti
A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
BioMed Research International
author_facet A. Paffi
F. Apollonio
M. G. Puxeddu
M. Parazzini
G. d’Inzeo
P. Ravazzani
M. Liberti
author_sort A. Paffi
title A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_short A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_full A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_fullStr A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_full_unstemmed A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_sort numerical study to compare stimulations by intraoperative microelectrodes and chronic macroelectrodes in the dbs technique
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Deep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.
url http://dx.doi.org/10.1155/2013/262739
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