Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.

Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.

Cardiac inwardly rectifying Kir current (IK1) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 and Kir2.2 channel subunits. It has been shown that...

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Bibliographic Details
Main Authors: Daniel Scherer, Claudia Seyler, Panagiotis Xynogalos, Eberhard P Scholz, Dierk Thomas, Johannes Backs, Martin Andrassy, Mirko Völkers, Christoph A Karle, Hugo A Katus, Edgar Zitron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4877014?pdf=render

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