Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin.

Verification that cell lines used for cancer research are derived from malignant cells in primary tumors is imperative to avoid invalidation of study results. Retinoblastoma is a childhood ocular tumor that develops from loss of functional retinoblastoma protein (pRb) as a result of genetic or epige...

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Bibliographic Details
Main Authors: Wesley S Bond, Patricia Y Akinfenwa, Laszlo Perlaky, Mary Y Hurwitz, Richard L Hurwitz, Patricia Chévez-Barrios
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3691222?pdf=render

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