Application of Statistical Experimental Design and Surface Plot Technique to Optimize Oxygenated Apatite Synthesis

• Main Authors: Soumia Belouafa, Hassan Chaair, Khalid Digua
• Format: Article
• Language: English
• Published: Hindawi Limited 2020-01-01
• Series: Advances in Materials Science and Engineering
• Online Access: http://dx.doi.org/10.1155/2020/1034959

This work deals with oxygenated apatite synthesis from calcium chloride and phosphoric acid using a wet precipitation method. An experimental design is applied to precise the influence of the synthesis parameters (pH of the reaction medium, atomic ratio Ca/P of the reagents, concentration of the calcium solution (Ca2+), temperature of the reaction medium (T), and duration of the reaction (D)) on the chemical composition (Ca/P molar ratio, % O2, and % O22−). An empirical model was developed and validated by applying the ANOVA analysis incorporating the interaction effects of all parameters and optimized using the response surface methodology. A reproducible synthesis of more oxygenated apatite with speed of dissolution adaptable to that of the osseous neoformation and allowing a progressive diffusion of oxygenated species (Ca/P = 1.575) is attained.