The experience of polyhexanide usage as a part of wet environment in the treatment of limited burns

• Main Authors: A. S. Luzan, I. Yu. Aref'ev, I. A. Klemenova, N. G. Zasetskaya, P. V. Peretyagin
• Format: Article
• Language: Russian
• Published: Pavlov First Saint Petersburg State Medical University 2020-05-01
• Series: Вестник хирургии имени И.И. Грекова
• Subjects: burns; wet environment; polyhexanide; thermal trauma; treatment
• Online Access: https://www.vestnik-grekova.ru/jour/article/view/1402

INTRODUCTION. The results of the treatment of patients with restrictive burns I-II degrees are presented in the article. The OBJECTIVE of the research was to establish the efficiency of the usage of polyhexanide included in wet environment in the treatment of burns I-II degrees.METHODS AND MATERIALS. The research was conducted in 2 groups of patients. In the first group (N=33), local treatment of hand wounds was performed in condition of wet environment created by isotonic solution of sodium chloride, in the second group (N=18) - with usage of polyhexanide as antiseptic and isotonic chloride saline solution. For evaluation of efficiency of the treatment, we studied the terms of the beginning of epithelialization of the wound surface, pain syndrome severity, microcirculation and conducted microbiological research of wound exudate.RESULTS. The appearance of the first signs of wound epithelialization after the beginnings of treatment was observed in 1.5 times in average sooner in the second group than in the first group. Pain syndrome was jugulated by the 3rd day in the first (research) group in 19 % of cases, in the second (control) group - in 46 % (p<0.05). In the second group, perfusion of tissues in the border area reduced, in the same time in the first group, it remained unchanged. The number of swabbing cases with Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae and Enterococcus faecalis increased in the first group by the 3rd day in contrast with the second group, where such cases was not noted or occurred significantly less often.CONCLUSION. The usage of polyhexanide as a part of wet environment promotes the reduction of wound surface swabbing level that allows to speed up the appearance of the first signs of wound epithelialization, reduces the severity of pain syndrome, and modeling of tissue microcirculation in periwound area.