Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.

Bibliographic Details
Main Authors:	Eunhee Choi, Sotaro Kikuchi, Haishan Gao, Karolina Brodzik, Ibrahim Nassour, Adam Yopp, Amit G. Singal, Hao Zhu, Hongtao Yu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09318-3

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spelling	doaj-819277c64772481c8648587394125c812021-05-11T12:37:29ZengNature Publishing GroupNature Communications2041-17232019-04-0110111710.1038/s41467-019-09318-3Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signalingEunhee Choi0Sotaro Kikuchi1Haishan Gao2Karolina Brodzik3Ibrahim Nassour4Adam Yopp5Amit G. Singal6Hao Zhu7Hongtao Yu8Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical CenterHoward Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical CenterHoward Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical CenterHoward Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical CenterChildren’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical CenterChildren’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical CenterChildren’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical CenterChildren’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical CenterHoward Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical CenterThe mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.https://doi.org/10.1038/s41467-019-09318-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eunhee Choi Sotaro Kikuchi Haishan Gao Karolina Brodzik Ibrahim Nassour Adam Yopp Amit G. Singal Hao Zhu Hongtao Yu
spellingShingle	Eunhee Choi Sotaro Kikuchi Haishan Gao Karolina Brodzik Ibrahim Nassour Adam Yopp Amit G. Singal Hao Zhu Hongtao Yu Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling Nature Communications
author_facet	Eunhee Choi Sotaro Kikuchi Haishan Gao Karolina Brodzik Ibrahim Nassour Adam Yopp Amit G. Singal Hao Zhu Hongtao Yu
author_sort	Eunhee Choi
title	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_short	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_full	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_fullStr	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_full_unstemmed	Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
title_sort	mitotic regulators and the shp2-mapk pathway promote ir endocytosis and feedback regulation of insulin signaling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	The mechanisms promoting insulin resistance at the receptor level are poorly understood. Here, Choi et al. show that mitotic proteins and the SHP2-MAPK pathway regulate receptor endocytosis and insulin signaling feedback, identifying a potential role for SHP2 inhibitors to treat diabetes.
url	https://doi.org/10.1038/s41467-019-09318-3
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Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

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