Clinical and course indicators of bipolar disorder type I with and without opioid dependence

• Main Authors: Amir Shabani, Atefeh Ghanbari Jolfaei, Hajar Ahmadi Vazmalaei, Azizeh Afkham Ebrahimi, Morteza Naserbakht
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Journal of Research in Medical Sciences
• Subjects: Bipolar Disorder; Substance Dependence; Substance Abuse; Opioid; Outcome
• Online Access: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2010;volume=15;issue=1;spage=20;epage=26;aulast=Shabani

Background: The existing evidence about the clinical situations of the bipolar patients with opioid dependence is scarce. The present study was carried out to compare the clinical features and course of the bipolar disorder type I re-garding the two subgroups of opioid dependent and non- dependent. Methods: There were 178 adult patients with bipolar disorder type I consecutively referred to the Iran Hospital of Psy-chiatry, Tehran, Iran, from January 2008 to January 2009 who enrolled in the study. The Persian Structured Clinical Interview for DSM- IV axis I disorders (SCID- I), HDRS- 17, and Y- MRS were administered for all patients. Other clini-cal information was gathered through the face- to- face interviews with the probands and the hospital records. The T test, Chi square test and logistic regression were used to analyze the data. Results: The mean age of probands were 33.6 ± 11.1 years old and they were mostly male. Among the evaluated indi-ces, the factors gender, anxiety disorders comorbidity, non- adherence, and positive family history were different sig-nificantly and independently from the other studied factors between opioid dependent and non- dependent bipolar pa-tients. Conclusions: Despite some differences, the opioid dependent and non- dependent bipolar patients did not have any significant difference regarding most of the examined clinical and course indices.