Polymorphism of regulators of apoptosis and growth factors genes in chronic lymphatic leukemia

• Main Authors: Viktorova T.V., Karimov D.O., Bakirov В.A.
• Format: Article
• Language: Russian
• Published: Saratov State Medical University 2011-12-01
• Series: Саратовский научно-медицинский журнал
• Subjects: chronic lymphocytic leukaemia; genetic polymorphism; oncogenesis genes
• Online Access: http://www.ssmj.ru/system/files/201104_827-831.pdf

The objective of the research is to study the role of polymorphic variants of Tumor Necrosis Factor (TNF) — a (TNFA), Bcl2-associated X protein (BAX) p53-Binding Protein (MDM2), vascular endothelial growth factor (VEGFA) and basic fibroblast growth factor (bFGF) genes in chronic lymphocytic leukemia (CLL). Methods: The comparative analysis of alleles and genotypes distributions in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out. Results: Analysis of the distribution frequency of genotypes and alleles of the genes studied has showed an increase in frequency of genotypes GG and allele G polymorphic locus-308G> A TNFA gene, GG and allele G of the polymorphic locus-248G>A BAX gene, allele G of the polymorphic locus 309T> G gene MDM2 and allele С polymorphic locus 773C>T bFGF gene in patients with CLL