Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity

Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity

Oncolytic Semliki Forest virus (SFV) has been suggested as a potential candidate for the treatment of glioblastoma and neuroblastoma. However, the oncolytic capacity of SFV is restricted by the anti-viral type-I interferon (IFN) response. The aim of this study was to increase the oncolytic capacity...

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Bibliographic Details
Main Authors:	Tina Sarén, Mohanraj Ramachandran, Miika Martikainen, Di Yu
Format:	Article
Language:	English
Published:	Elsevier 2017-12-01
Series:	Molecular Therapy: Oncolytics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2372770517300451

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