Alendronate Release from UHMWPE-Based Biomaterials in Relation to Particle Size of the GUR Powder for Manufacturing

Alendronate Release from UHMWPE-Based Biomaterials in Relation to Particle Size of the GUR Powder for Manufacturing

Ultra-high molecular weight polyethylene (UHMWPE) is widely used in endoprosthetics and has been the subject of countless studies. This project investigates the dependence of alendronate (AL) release on the molecular weight of the UHMWPE used (GUR1020 and GUR1050). A 0.5 wt% AL was added to the UHMW...

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Bibliographic Details
Main Authors: Michael Seidenstuecker, Julia Weber, Sergio H. Latorre, Brigitte Straub, Ulrich Matthes, Christian Friedrich, Hermann O. Mayr, Anke Bernstein
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Materials
Subjects:
UHMWPE
GUR1020
GUR1050
alendronate
osteoporosis
aseptic loosening
drug release
HPLC
Online Access:https://www.mdpi.com/1996-1944/12/11/1832

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