Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)

<p>Abstract</p> <p>Background</p> <p>The start of chemotherapy usually requires a delay of about 4 weeks after surgical resection of colorectal cancer. However, there is no evidence for the required length of this delay interval. In addition, there is a chance that a pa...

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Main Authors: Yoshida Yoichiro, Hoshino Seiichiro, Aisu Naoya, Naito Masayasu, Miyake Toru, Tanimura Syu, Yamashita Yuichi
Format: Article
Language:English
Published: BMC 2013-02-01
Series:World Journal of Surgical Oncology
Subjects:
Online Access:http://www.wjso.com/content/11/1/39
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spelling doaj-8167dc46bead4134bfc07b447fbea9792020-11-25T00:37:54ZengBMCWorld Journal of Surgical Oncology1477-78192013-02-011113910.1186/1477-7819-11-39Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)Yoshida YoichiroHoshino SeiichiroAisu NaoyaNaito MasayasuMiyake ToruTanimura SyuYamashita Yuichi<p>Abstract</p> <p>Background</p> <p>The start of chemotherapy usually requires a delay of about 4 weeks after surgical resection of colorectal cancer. However, there is no evidence for the required length of this delay interval. In addition, there is a chance that a patient may die because postoperative chemotherapy was not started soon enough and a metastatic tumor was able to develop rapidly. We therefore conducted a pilot study to determine the safety and feasibility of an early start of chemotherapy after the resection of colorectal cancer with distant metastases.</p> <p>Methods</p> <p>Five patients were enrolled. They received XELOX therapy (130 mg/m2 of oxaliplatin on day 1 plus 1,000 mg/m2 of capecitabine twice daily on days 1 to 14) on the 7th postoperative day and XELOX + bevacizumab (7.5 mg/kg of bevacizumab on day 1) after the 2nd cycle of chemotherapy.</p> <p>Results</p> <p>Five patients underwent open surgery. The procedures included right hemicolectomy in 1 patient, sigmoidectomy in 2 patients, high anterior resection in 1 patient, and Hartmann procedure in 1 patient. All patients started chemotherapy on postoperative day 7. The median number of cycles of chemotherapy was 11 (8 to 22). No postoperative complications were observed. The tumor reduction rate was 44.3% (32.0 to 66.6%). Progression-free survival was 10.3 months.</p> <p>Conclusions</p> <p>An early start of chemotherapy after surgery is feasible and safe. These findings suggest possible changes in the start time of chemotherapy after surgery in the future. We have already started a new phase II trial to confirm the effects of the early start of chemotherapy after surgery.</p> <p>Trial registration</p> <p>UMIN000004361.</p> http://www.wjso.com/content/11/1/39Colorectal cancerChemotherapySurgeryXELOXEarly start
collection DOAJ
language English
format Article
sources DOAJ
author Yoshida Yoichiro
Hoshino Seiichiro
Aisu Naoya
Naito Masayasu
Miyake Toru
Tanimura Syu
Yamashita Yuichi
spellingShingle Yoshida Yoichiro
Hoshino Seiichiro
Aisu Naoya
Naito Masayasu
Miyake Toru
Tanimura Syu
Yamashita Yuichi
Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)
World Journal of Surgical Oncology
Colorectal cancer
Chemotherapy
Surgery
XELOX
Early start
author_facet Yoshida Yoichiro
Hoshino Seiichiro
Aisu Naoya
Naito Masayasu
Miyake Toru
Tanimura Syu
Yamashita Yuichi
author_sort Yoshida Yoichiro
title Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)
title_short Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)
title_full Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)
title_fullStr Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)
title_full_unstemmed Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01)
title_sort pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (pearl star 01)
publisher BMC
series World Journal of Surgical Oncology
issn 1477-7819
publishDate 2013-02-01
description <p>Abstract</p> <p>Background</p> <p>The start of chemotherapy usually requires a delay of about 4 weeks after surgical resection of colorectal cancer. However, there is no evidence for the required length of this delay interval. In addition, there is a chance that a patient may die because postoperative chemotherapy was not started soon enough and a metastatic tumor was able to develop rapidly. We therefore conducted a pilot study to determine the safety and feasibility of an early start of chemotherapy after the resection of colorectal cancer with distant metastases.</p> <p>Methods</p> <p>Five patients were enrolled. They received XELOX therapy (130 mg/m2 of oxaliplatin on day 1 plus 1,000 mg/m2 of capecitabine twice daily on days 1 to 14) on the 7th postoperative day and XELOX + bevacizumab (7.5 mg/kg of bevacizumab on day 1) after the 2nd cycle of chemotherapy.</p> <p>Results</p> <p>Five patients underwent open surgery. The procedures included right hemicolectomy in 1 patient, sigmoidectomy in 2 patients, high anterior resection in 1 patient, and Hartmann procedure in 1 patient. All patients started chemotherapy on postoperative day 7. The median number of cycles of chemotherapy was 11 (8 to 22). No postoperative complications were observed. The tumor reduction rate was 44.3% (32.0 to 66.6%). Progression-free survival was 10.3 months.</p> <p>Conclusions</p> <p>An early start of chemotherapy after surgery is feasible and safe. These findings suggest possible changes in the start time of chemotherapy after surgery in the future. We have already started a new phase II trial to confirm the effects of the early start of chemotherapy after surgery.</p> <p>Trial registration</p> <p>UMIN000004361.</p>
topic Colorectal cancer
Chemotherapy
Surgery
XELOX
Early start
url http://www.wjso.com/content/11/1/39
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