Improved Identification of Small Open Reading Frames Encoded Peptides by Top-Down Proteomic Approaches and De Novo Sequencing

Improved Identification of Small Open Reading Frames Encoded Peptides by Top-Down Proteomic Approaches and De Novo Sequencing

Small open reading frames (sORFs) have translational potential to produce peptides that play essential roles in various biological processes. Nevertheless, many sORF-encoded peptides (SEPs) are still on the prediction level. Here, we construct a strategy to analyze SEPs by combining top-down and de...

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Bibliographic Details
Main Authors: Bing Wang, Zhiwei Wang, Ni Pan, Jiangmei Huang, Cuihong Wan
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
sORF-encoded peptides
de novo sequencing
top-down
non-ATG start codon
sequence coverage
Online Access:https://www.mdpi.com/1422-0067/22/11/5476

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