Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro

• Main Authors: Buckley McCall, Connor K. McPartland, Reece Moore, Anastasia Frank-Kamenetskii, Brian W. Booth
• Format: Article
• Language: English
• Published: MDPI AG 2018-10-01
• Series: Antioxidants
• Subjects: antioxidant; astaxanthin; breast cancer; carotenoid; migration; proliferation; Xanthoph
• Online Access: http://www.mdpi.com/2076-3921/7/10/135

Astaxanthin (ASX) is a marine-based ketocarotenoid; an accessory pigment in plants in that it has many different potential functions. ASX is an antioxidant that is notably more potent than many other antioxidants. Antioxidants have anti-inflammatory and oxidative stress-reducing properties to potentially reduce the incidence of cancer or inhibit the expansion of tumor cells. In this study, we tested the hypothesis that ASX would inhibit proliferation and migration of breast cancer cells in vitro. We found that application of ASX significantly reduced proliferation rates and inhibited breast cancer cell migration compared to control normal breast epithelial cells. Based on these results, further investigation of the effects of ASX on not only breast cancer cells, but other forms of tumor cells, should be carried out.