Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants.

Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants.

Mal3p and Tip1p are the fission yeast (Schizosaccharomyces pombe) homologues of EB1 and CLIP-170, two conserved microtubule plus end tracking proteins (+TIPs). These proteins are crucial regulators of microtubule dynamics. Using electron tomography, we carried out a high-resolution analysis of the p...

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Bibliographic Details
Main Authors: Johanna L Höög, Stephen M Huisman, Damian Brunner, Claude Antony
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3627915?pdf=render

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