STAT3 Activation in Combination with NF-KappaB Inhibition Induces Tolerogenic Dendritic Cells with High Therapeutic Potential to Attenuate Collagen-Induced Arthritis
Dendritic cells (DCs) have the ability to induce tolerance or inflammation in response to self-antigens, which makes them fundamental players in autoimmunity. In this regard, immunogenic DCs produce IL-12 and IL-23 favouring the acquisition of Th1 and Th17 inflammatory phenotypes, respectively, by a...
Main Authors: | Carolina Prado, Valentina Ugalde, Hugo González, Alicia Figueroa, Ernesto López, Alvaro Lladser, Rodrigo Pacheco |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2019-01-01
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Series: | Journal of Immunology Research |
Online Access: | http://dx.doi.org/10.1155/2019/1982570 |
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