A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD in preclinical mouse models. H...

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Bibliographic Details
Main Authors: Antje Bruckbauer, Jheelam Banerjee, Lizhi Fu, Fenfen Li, Qiang Cao, Xin Cui, Rui Wu, Hang Shi, Bingzhong Xue, Michael B. Zemel
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.1155/2016/9185987

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