One-pot synthesis of carbazole based 3-hydroxy-4H-chromen-4-ones by modified Algar-Flynn-Oyamada reaction and their antimicrobial activity

• Main Authors: Ashok Dongamanti, Ravi Sidda, Lakshmi Vijaya Bommidi, Ganesh Arram
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2015-01-01
• Series: Journal of the Serbian Chemical Society
• Subjects: 2-(9-ethyl-9H-carbazol-3-yl)-3-hydroxy-4H-chromen-4-ones; modified Algar-Flynn-Oyamada reaction; antimicrobial activity
• Online Access: http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391500051A.pdf
• ISSN: 0352-5139; 1820-7421

A new series of 2-(9-ethyl-9H-carbazol-3-yl)-3-hydroxy-4Hchromen-4-ones have been synthesized from substituted 2-hydroxy acetophenones and 9-ethyl-9H-carbazole-3-carbaldehyde using NaOH and H2O2 by modified Algar-Flynn-Oyamada reaction. In this method flavonols are synthesized without isolating chalcones in good yields (70-82%). The structures of the compounds were established on the basis of 1H-NMR, 13CNMR, FT-IR and mass spectral and analytical data. All the compounds were evaluated for their antimicrobial activity against bacteria such as Staphylococus aureus, Bacillus subtilis, Escherichia coli and Klebsiella pneumoniae as well as fungi such as Aspergillus flavus and Fusarium oxysporum.