Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.

Bibliographic Details
Main Authors:	Nawal Maïssa, Valentina Covarelli, Sébastien Janel, Beatrice Durel, Nandi Simpson, Sandra C. Bernard, Liliana Pardo-Lopez, Haniaa Bouzinba-Ségard, Camille Faure, Mark G.H. Scott, Mathieu Coureuil, Philippe C. Morand, Frank Lafont, Xavier Nassif, Stefano Marullo, Sandrine Bourdoulous
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15764

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spelling	doaj-812ccd1878054e24ab2fafea122fa20e2021-05-11T07:48:07ZengNature Publishing GroupNature Communications2041-17232017-06-018111510.1038/ncomms15764Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4Nawal Maïssa0Valentina Covarelli1Sébastien Janel2Beatrice Durel3Nandi Simpson4Sandra C. Bernard5Liliana Pardo-Lopez6Haniaa Bouzinba-Ségard7Camille Faure8Mark G.H. Scott9Mathieu Coureuil10Philippe C. Morand11Frank Lafont12Xavier Nassif13Stefano Marullo14Sandrine Bourdoulous15Department of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinCellular Microbiology and Physics of infection, Center for Infection and Immunity of Lille, Institut Pasteur de LilleDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinInserm, unité U1151, Institut-Necker-Enfants-MaladesDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinCellular Microbiology and Physics of infection, Center for Infection and Immunity of Lille, Institut Pasteur de LilleInserm, unité U1151, Institut-Necker-Enfants-MaladesDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinDepartment of Infection, Inserm, U1016, Immunity and Inflammation, Institut CochinNeisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.https://doi.org/10.1038/ncomms15764
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nawal Maïssa Valentina Covarelli Sébastien Janel Beatrice Durel Nandi Simpson Sandra C. Bernard Liliana Pardo-Lopez Haniaa Bouzinba-Ségard Camille Faure Mark G.H. Scott Mathieu Coureuil Philippe C. Morand Frank Lafont Xavier Nassif Stefano Marullo Sandrine Bourdoulous
spellingShingle	Nawal Maïssa Valentina Covarelli Sébastien Janel Beatrice Durel Nandi Simpson Sandra C. Bernard Liliana Pardo-Lopez Haniaa Bouzinba-Ségard Camille Faure Mark G.H. Scott Mathieu Coureuil Philippe C. Morand Frank Lafont Xavier Nassif Stefano Marullo Sandrine Bourdoulous Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4 Nature Communications
author_facet	Nawal Maïssa Valentina Covarelli Sébastien Janel Beatrice Durel Nandi Simpson Sandra C. Bernard Liliana Pardo-Lopez Haniaa Bouzinba-Ségard Camille Faure Mark G.H. Scott Mathieu Coureuil Philippe C. Morand Frank Lafont Xavier Nassif Stefano Marullo Sandrine Bourdoulous
author_sort	Nawal Maïssa
title	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_short	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_full	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_fullStr	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_full_unstemmed	Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
title_sort	strength of neisseria meningitidis binding to endothelial cells requires highly-ordered cd147/β2-adrenoceptor clusters assembled by alpha-actinin-4
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-06-01
description	Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.
url	https://doi.org/10.1038/ncomms15764
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Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

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