Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions
Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07481-7 |
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doaj-811fe916ab7f4aa8a28b241ddb5f61db2021-05-11T09:31:49ZengNature Publishing GroupNature Communications2041-17232018-11-019111710.1038/s41467-018-07481-7Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functionsNoboru Ishiyama0Ritu Sarpal1Megan N. Wood2Samantha K. Barrick3Tadateru Nishikawa4Hanako Hayashi5Anna B. Kobb6Annette S. Flozak7Alex Yemelyanov8Rodrigo Fernandez-Gonzalez9Shigenobu Yonemura10Deborah E. Leckband11Cara J. Gottardi12Ulrich Tepass13Mitsuhiko Ikura14Princess Margaret Cancer Centre, University Health NetworkDepartment of Cell and Systems Biology, University of TorontoDepartment of Medicine, Northwestern University Feinberg School of MedicineDepartment of Chemistry, University of IllinoisPrincess Margaret Cancer Centre, University Health NetworkRIKEN Center for Life Science Technologies, KobeInstitute of Biomaterials and Biomedical Engineering, University of TorontoDepartment of Medicine, Northwestern University Feinberg School of MedicineDepartment of Medicine, Northwestern University Feinberg School of MedicineDepartment of Cell and Systems Biology, University of TorontoRIKEN Center for Life Science Technologies, KobeDepartment of Chemistry, University of IllinoisDepartment of Medicine, Northwestern University Feinberg School of MedicineDepartment of Cell and Systems Biology, University of TorontoPrincess Margaret Cancer Centre, University Health NetworkCell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.https://doi.org/10.1038/s41467-018-07481-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Noboru Ishiyama Ritu Sarpal Megan N. Wood Samantha K. Barrick Tadateru Nishikawa Hanako Hayashi Anna B. Kobb Annette S. Flozak Alex Yemelyanov Rodrigo Fernandez-Gonzalez Shigenobu Yonemura Deborah E. Leckband Cara J. Gottardi Ulrich Tepass Mitsuhiko Ikura |
| spellingShingle |
Noboru Ishiyama Ritu Sarpal Megan N. Wood Samantha K. Barrick Tadateru Nishikawa Hanako Hayashi Anna B. Kobb Annette S. Flozak Alex Yemelyanov Rodrigo Fernandez-Gonzalez Shigenobu Yonemura Deborah E. Leckband Cara J. Gottardi Ulrich Tepass Mitsuhiko Ikura Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions Nature Communications |
| author_facet |
Noboru Ishiyama Ritu Sarpal Megan N. Wood Samantha K. Barrick Tadateru Nishikawa Hanako Hayashi Anna B. Kobb Annette S. Flozak Alex Yemelyanov Rodrigo Fernandez-Gonzalez Shigenobu Yonemura Deborah E. Leckband Cara J. Gottardi Ulrich Tepass Mitsuhiko Ikura |
| author_sort |
Noboru Ishiyama |
| title |
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions |
| title_short |
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions |
| title_full |
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions |
| title_fullStr |
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions |
| title_full_unstemmed |
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions |
| title_sort |
force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-11-01 |
| description |
Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin. |
| url |
https://doi.org/10.1038/s41467-018-07481-7 |
| work_keys_str_mv |
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1721449665520467968 |