POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION

POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION

XRCC1 Arg280His, XRCC2 Arg188His, XRCC3 Thr241Met genes polymorphism in lung cancer patients and healthy people of Kemerovo region has been studied. It is established that in the studied samples of distribution of frequencies of alleles and genotypes of the studied polymorphic markers had no deviati...

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Main Authors: A. V. Ryzhkova, V. I. Minina, M. L. Bakanova, R. A. Titov, Yu. E. Kulemin
Format: Article
Language:English
Published: Kemerovo State University 2014-09-01
Series:Вестник Кемеровского государственного университета
Subjects:
xrcc1
xrcc2
xrcc3 genes polymorphism
lung cancer
Online Access:https://vestnik.kemsu.ru/jour/article/view/1173
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spelling doaj-811e5164f06747dd8785d75f4705dd6c2020-11-25T02:43:18ZengKemerovo State UniversityВестник Кемеровского государственного университета2078-89752078-89832014-09-0103-326291172POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGIONA. V. Ryzhkova0V. I. Minina1M. L. Bakanova2R. A. Titov3Yu. E. Kulemin4Institute for Human Ecology of the Siberian branch of the RASKemerovo State University; Institute for Human Ecology of the Siberian branch of the RASInstitute for Human Ecology of the Siberian branch of the RASInstitute for Human Ecology of the Siberian branch of the RASKemerovo State University; Institute for Human Ecology of the Siberian branch of the RASXRCC1 Arg280His, XRCC2 Arg188His, XRCC3 Thr241Met genes polymorphism in lung cancer patients and healthy people of Kemerovo region has been studied. It is established that in the studied samples of distribution of frequencies of alleles and genotypes of the studied polymorphic markers had no deviation from Hardy-Weinberg equilibrium. The prevalence of XRCC3Met in the group of patients with lung cancer is statistically significantly higher than in healthy people. Also, there was a decrease in the frequency of Thr/Thr homozygotes of the XRCC3 gene in male patients with lung cancer. The obtained data are of significant interest for epidemiological studies of hereditary predisposition to the development of lung cancer.https://vestnik.kemsu.ru/jour/article/view/1173xrcc1xrcc2xrcc3 genes polymorphismlung cancer
collection DOAJ
language English
format Article
sources DOAJ
author A. V. Ryzhkova
V. I. Minina
M. L. Bakanova
R. A. Titov
Yu. E. Kulemin
spellingShingle A. V. Ryzhkova
V. I. Minina
M. L. Bakanova
R. A. Titov
Yu. E. Kulemin
POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
Вестник Кемеровского государственного университета
xrcc1
xrcc2
xrcc3 genes polymorphism
lung cancer
author_facet A. V. Ryzhkova
V. I. Minina
M. L. Bakanova
R. A. Titov
Yu. E. Kulemin
author_sort A. V. Ryzhkova
title POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
title_short POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
title_full POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
title_fullStr POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
title_full_unstemmed POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
title_sort polimorphism of xrcc1, xrcc2, xrcc3 genes in lung cancer patients and healthy people of kemerovo region
publisher Kemerovo State University
series Вестник Кемеровского государственного университета
issn 2078-8975
2078-8983
publishDate 2014-09-01
description XRCC1 Arg280His, XRCC2 Arg188His, XRCC3 Thr241Met genes polymorphism in lung cancer patients and healthy people of Kemerovo region has been studied. It is established that in the studied samples of distribution of frequencies of alleles and genotypes of the studied polymorphic markers had no deviation from Hardy-Weinberg equilibrium. The prevalence of XRCC3Met in the group of patients with lung cancer is statistically significantly higher than in healthy people. Also, there was a decrease in the frequency of Thr/Thr homozygotes of the XRCC3 gene in male patients with lung cancer. The obtained data are of significant interest for epidemiological studies of hereditary predisposition to the development of lung cancer.
topic xrcc1
xrcc2
xrcc3 genes polymorphism
lung cancer
url https://vestnik.kemsu.ru/jour/article/view/1173
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