Multiple-clade H5N1 influenza split vaccine elicits broad cross protection against lethal influenza virus challenge in mice by intranasal vaccination.

Multiple-clade H5N1 influenza split vaccine elicits broad cross protection against lethal influenza virus challenge in mice by intranasal vaccination.

<h4>Background</h4>The increase in recent outbreaks and unpredictable changes of highly pathogenic avian influenza (HPAI) H5N1 in birds and humans highlights the urgent need to develop a cross-protective H5N1 vaccine. We here report our development of a multiple-clade H5N1 influenza vacc...

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Bibliographic Details
Main Authors: Penghui Yang, Yueqiang Duan, Peirui Zhang, Zhiwei Li, Cheng Wang, Mei Dong, Chong Tang, Li Xing, Hongjing Gu, Zhongpeng Zhao, Xiufan Liu, Shaogeng Zhang, Xiliang Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22279575/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22279575/pdf/?tool=EBI

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