Pulmonary aspiration in preschool children with cystic fibrosis

Pulmonary aspiration in preschool children with cystic fibrosis

Abstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage...

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Main Authors: D. Clarke, I. Gorman, F. Ringholz, M. McDermott, DW. Cox, P. Greally, B. Linnane, P. Mc Nally
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Respiratory Research
Online Access:http://link.springer.com/article/10.1186/s12931-018-0954-1
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spelling doaj-8104a2f343354ac2afc5b27459050c052020-11-25T02:54:57ZengBMCRespiratory Research1465-993X2018-12-011911310.1186/s12931-018-0954-1Pulmonary aspiration in preschool children with cystic fibrosisD. Clarke0I. Gorman1F. Ringholz2M. McDermott3DW. Cox4P. Greally5B. Linnane6P. Mc Nally7National Children’s Research CentreNational Children’s Research CentreNational Children’s Research CentreOur Lady’s Children’s HospitalNational Children’s Research CentreNational Children’s HospitalNational Children’s Research CentreNational Children’s Research CentreAbstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.http://link.springer.com/article/10.1186/s12931-018-0954-1
collection DOAJ
language English
format Article
sources DOAJ
author D. Clarke
I. Gorman
F. Ringholz
M. McDermott
DW. Cox
P. Greally
B. Linnane
P. Mc Nally
spellingShingle D. Clarke
I. Gorman
F. Ringholz
M. McDermott
DW. Cox
P. Greally
B. Linnane
P. Mc Nally
Pulmonary aspiration in preschool children with cystic fibrosis
Respiratory Research
author_facet D. Clarke
I. Gorman
F. Ringholz
M. McDermott
DW. Cox
P. Greally
B. Linnane
P. Mc Nally
author_sort D. Clarke
title Pulmonary aspiration in preschool children with cystic fibrosis
title_short Pulmonary aspiration in preschool children with cystic fibrosis
title_full Pulmonary aspiration in preschool children with cystic fibrosis
title_fullStr Pulmonary aspiration in preschool children with cystic fibrosis
title_full_unstemmed Pulmonary aspiration in preschool children with cystic fibrosis
title_sort pulmonary aspiration in preschool children with cystic fibrosis
publisher BMC
series Respiratory Research
issn 1465-993X
publishDate 2018-12-01
description Abstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.
url http://link.springer.com/article/10.1186/s12931-018-0954-1
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AT igorman pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
AT fringholz pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
AT mmcdermott pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
AT dwcox pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
AT pgreally pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
AT blinnane pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
AT pmcnally pulmonaryaspirationinpreschoolchildrenwithcysticfibrosis
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