Pulmonary aspiration in preschool children with cystic fibrosis

Pulmonary aspiration in preschool children with cystic fibrosis

Abstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage...

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Bibliographic Details
Main Authors: D. Clarke, I. Gorman, F. Ringholz, M. McDermott, DW. Cox, P. Greally, B. Linnane, P. Mc Nally
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Respiratory Research
Online Access:http://link.springer.com/article/10.1186/s12931-018-0954-1
Description
Summary:Abstract Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.
ISSN:1465-993X

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