Reduced higher dimensional temporal dynamism in neurofibromatosis type 1

Reduced higher dimensional temporal dynamism in neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a common single gene disorder resulting in multi-organ involvement. In addition to physical manifestations such as characteristic pigmentary changes, nerve sheath tumors, and skeletal abnormalities, NF1 is also associated with increased rates of learning disabilitie...

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Main Authors: Eva Mennigen, Peter Schuette, Ariana Vajdi, Laura Pacheco, Tena Rosser, Carrie E. Bearden
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158219300427
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spelling doaj-81015b93f97748ee9c26292fe88f9a0d2020-11-25T02:30:55ZengElsevierNeuroImage: Clinical2213-15822019-01-0122Reduced higher dimensional temporal dynamism in neurofibromatosis type 1Eva Mennigen0Peter Schuette1Ariana Vajdi2Laura Pacheco3Tena Rosser4Carrie E. Bearden5Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USADepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USADepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USADepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USAChildren's Hospital Los Angeles, Los Angeles, CA, USA; University of Southern California, Keck School of Medicine, Los Angeles, CA, USADepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA; Department of Psychology, University of California, Los Angeles, CA, USA; Corresponding author at: UCLA Semel Institute for Neuroscience & Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90095, USA.Neurofibromatosis type 1 (NF1) is a common single gene disorder resulting in multi-organ involvement. In addition to physical manifestations such as characteristic pigmentary changes, nerve sheath tumors, and skeletal abnormalities, NF1 is also associated with increased rates of learning disabilities, attention deficit hyperactivity disorder, and autism spectrum disorder. While there are established NF1-related structural brain anomalies, including brain overgrowth and white matter disruptions, little is known regarding patterns of functional connectivity in NF1. Here, we sought to investigate functional network connectivity (FNC) in a well-characterized sample of NF1 participants (n = 30) vs. age- and sex-matched healthy controls (n = 30). We conducted a comprehensive investigation of both static as well as dynamic FNC and meta-state analysis, a novel approach to examine higher-dimensional temporal dynamism of whole-brain connectivity.We found that static FNC of the cognitive control domain is altered in NF1 participants. Specifically, connectivity between anterior cognitive control areas and the cerebellum is decreased, whereas connectivity within the cognitive control domain is increased in NF1 participants relative to healthy controls. These alterations are independent of IQ.Dynamic FNC analysis revealed that NF1 participants spent more time in a state characterized by whole-brain hypoconnectivity relative to healthy controls. However, connectivity strength of dynamic states did not differ between NF1 participants and healthy controls.NF1 participants exhibited also reduced higher-dimensional dynamism of whole-brain connectivity, suggesting that temporal fluctuations of FNC are reduced. Given that similar findings have been observed in individuals with schizophrenia, higher occurrence of hypoconnected dynamic states and reduced temporal dynamism may be more general indicators of global brain dysfunction and not specific to either disorder. Keywords: Neurofibromatosis type 1, Functional connectivity, Dynamic functional network connectivity, Meta-state analysis, Group independent component analysishttp://www.sciencedirect.com/science/article/pii/S2213158219300427
collection DOAJ
language English
format Article
sources DOAJ
author Eva Mennigen
Peter Schuette
Ariana Vajdi
Laura Pacheco
Tena Rosser
Carrie E. Bearden
spellingShingle Eva Mennigen
Peter Schuette
Ariana Vajdi
Laura Pacheco
Tena Rosser
Carrie E. Bearden
Reduced higher dimensional temporal dynamism in neurofibromatosis type 1
NeuroImage: Clinical
author_facet Eva Mennigen
Peter Schuette
Ariana Vajdi
Laura Pacheco
Tena Rosser
Carrie E. Bearden
author_sort Eva Mennigen
title Reduced higher dimensional temporal dynamism in neurofibromatosis type 1
title_short Reduced higher dimensional temporal dynamism in neurofibromatosis type 1
title_full Reduced higher dimensional temporal dynamism in neurofibromatosis type 1
title_fullStr Reduced higher dimensional temporal dynamism in neurofibromatosis type 1
title_full_unstemmed Reduced higher dimensional temporal dynamism in neurofibromatosis type 1
title_sort reduced higher dimensional temporal dynamism in neurofibromatosis type 1
publisher Elsevier
series NeuroImage: Clinical
issn 2213-1582
publishDate 2019-01-01
description Neurofibromatosis type 1 (NF1) is a common single gene disorder resulting in multi-organ involvement. In addition to physical manifestations such as characteristic pigmentary changes, nerve sheath tumors, and skeletal abnormalities, NF1 is also associated with increased rates of learning disabilities, attention deficit hyperactivity disorder, and autism spectrum disorder. While there are established NF1-related structural brain anomalies, including brain overgrowth and white matter disruptions, little is known regarding patterns of functional connectivity in NF1. Here, we sought to investigate functional network connectivity (FNC) in a well-characterized sample of NF1 participants (n = 30) vs. age- and sex-matched healthy controls (n = 30). We conducted a comprehensive investigation of both static as well as dynamic FNC and meta-state analysis, a novel approach to examine higher-dimensional temporal dynamism of whole-brain connectivity.We found that static FNC of the cognitive control domain is altered in NF1 participants. Specifically, connectivity between anterior cognitive control areas and the cerebellum is decreased, whereas connectivity within the cognitive control domain is increased in NF1 participants relative to healthy controls. These alterations are independent of IQ.Dynamic FNC analysis revealed that NF1 participants spent more time in a state characterized by whole-brain hypoconnectivity relative to healthy controls. However, connectivity strength of dynamic states did not differ between NF1 participants and healthy controls.NF1 participants exhibited also reduced higher-dimensional dynamism of whole-brain connectivity, suggesting that temporal fluctuations of FNC are reduced. Given that similar findings have been observed in individuals with schizophrenia, higher occurrence of hypoconnected dynamic states and reduced temporal dynamism may be more general indicators of global brain dysfunction and not specific to either disorder. Keywords: Neurofibromatosis type 1, Functional connectivity, Dynamic functional network connectivity, Meta-state analysis, Group independent component analysis
url http://www.sciencedirect.com/science/article/pii/S2213158219300427
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