Design, Synthesis and Molecular Docking Analysis of Flavonoid Derivatives as Potential Telomerase Inhibitors

Design, Synthesis and Molecular Docking Analysis of Flavonoid Derivatives as Potential Telomerase Inhibitors

Based on the structural scaffolds of natural products, two series of flavonoid derivatives, for a total of twelve compounds, were designed and synthesized as potential human telomerase inhibitors. Using a modified TRAP-PCR assay, compound <b>5c</b> exhibited the most potent inhibitory ac...

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Bibliographic Details
Main Authors: Zhan-Fang Fan, Sai-Tim Ho, Rui Wen, Ya Fu, Lei Zhang, Jian Wang, Chun Hu, Pang-Chui Shaw, Yang Liu, Mao-Sheng Cheng
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
human telomerase holoenzyme
flavonoid
antiproliferative activity
molecular modeling
Online Access:https://www.mdpi.com/1420-3049/24/17/3180

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