Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization.

Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization.

Here we investigate the role of Phosphatidylinositol (4,5) bisphosphate (PIP(2)) in the physiological activation of primary murine T cells by antigen presenting cells (APC) by addressing two principal challenges in PIP(2) biology. First, PIP(2) is a regulator of cytoskeletal dynamics and a substrate...

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Bibliographic Details
Main Authors: Yi Sun, Radhika D Dandekar, Yuntao S Mao, Helen L Yin, Christoph Wülfing
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3214035?pdf=render

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