Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation
Abstract Objective Standard rodent sepsis models as cecal ligation and puncture models (CLP) or cecal ligation and incision models (CLI) are frequently not suited experiments, mainly because they lack surgical repair, and they are difficult to control for severity. The colon ascendens stent peritoni...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-01-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-020-05438-y |
| id |
doaj-80f29ca984f84b6baa5eee5ac5838cd8 |
|---|---|
| record_format |
Article |
| spelling |
doaj-80f29ca984f84b6baa5eee5ac5838cd82021-01-10T12:51:13ZengBMCBMC Research Notes1756-05002021-01-011411510.1186/s13104-020-05438-yDescription of a rat model of polymicrobial abdominal sepsis mimicking human colon perforationJulia M. Utiger0Michael Glas1Anja Levis2Josef Prazak3Matthias Haenggi4Department of Intensive Care Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Intensive Care Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Intensive Care Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Intensive Care Medicine, Bern University Hospital, Inselspital, University of BernDepartment of Intensive Care Medicine, Bern University Hospital, Inselspital, University of BernAbstract Objective Standard rodent sepsis models as cecal ligation and puncture models (CLP) or cecal ligation and incision models (CLI) are frequently not suited experiments, mainly because they lack surgical repair, and they are difficult to control for severity. The colon ascendens stent peritonitis model (CASP) overcomes some of these limitations. Result Here we present our modification of the rodent CASP model, where severity of sepsis can be controlled by timing of surgical repair and treatment, and by diameter of the stent. Further, basic hemodynamic monitoring (blood pressure and heart rate) and frequent blood sampling can be achieved, which might guide further treatment.https://doi.org/10.1186/s13104-020-05438-yRodentHemodynamic monitoringCecumColonAscendingPunctures |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Julia M. Utiger Michael Glas Anja Levis Josef Prazak Matthias Haenggi |
| spellingShingle |
Julia M. Utiger Michael Glas Anja Levis Josef Prazak Matthias Haenggi Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation BMC Research Notes Rodent Hemodynamic monitoring Cecum Colon Ascending Punctures |
| author_facet |
Julia M. Utiger Michael Glas Anja Levis Josef Prazak Matthias Haenggi |
| author_sort |
Julia M. Utiger |
| title |
Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation |
| title_short |
Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation |
| title_full |
Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation |
| title_fullStr |
Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation |
| title_full_unstemmed |
Description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation |
| title_sort |
description of a rat model of polymicrobial abdominal sepsis mimicking human colon perforation |
| publisher |
BMC |
| series |
BMC Research Notes |
| issn |
1756-0500 |
| publishDate |
2021-01-01 |
| description |
Abstract Objective Standard rodent sepsis models as cecal ligation and puncture models (CLP) or cecal ligation and incision models (CLI) are frequently not suited experiments, mainly because they lack surgical repair, and they are difficult to control for severity. The colon ascendens stent peritonitis model (CASP) overcomes some of these limitations. Result Here we present our modification of the rodent CASP model, where severity of sepsis can be controlled by timing of surgical repair and treatment, and by diameter of the stent. Further, basic hemodynamic monitoring (blood pressure and heart rate) and frequent blood sampling can be achieved, which might guide further treatment. |
| topic |
Rodent Hemodynamic monitoring Cecum Colon Ascending Punctures |
| url |
https://doi.org/10.1186/s13104-020-05438-y |
| work_keys_str_mv |
AT juliamutiger descriptionofaratmodelofpolymicrobialabdominalsepsismimickinghumancolonperforation AT michaelglas descriptionofaratmodelofpolymicrobialabdominalsepsismimickinghumancolonperforation AT anjalevis descriptionofaratmodelofpolymicrobialabdominalsepsismimickinghumancolonperforation AT josefprazak descriptionofaratmodelofpolymicrobialabdominalsepsismimickinghumancolonperforation AT matthiashaenggi descriptionofaratmodelofpolymicrobialabdominalsepsismimickinghumancolonperforation |
| _version_ |
1724342225275453440 |