Role of Hydrogen Peroxide in Cyclosporine-Induced Renal Tubular Cell (LLC-PK1) Injury

Role of Hydrogen Peroxide in Cyclosporine-Induced Renal Tubular Cell (LLC-PK1) Injury

We examined the role of hydrogen peroxide production in cyclosporine A (CsA)-induced LLC-PK1 injury. After exposure to CsA (0.1 μM – 100 μM), cytotoxicity assessed by lactate dehydrogenase release to the media increased dose-dependently. LLC-PK1 cells produced hydrogen peroxide, visualized by 2,7-di...

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Bibliographic Details
Main Authors:	Masashi Nishida, Hiroshi Ogawa, Megumi Tamai, Kohhei Ishiwari, Kenji Hamaoka
Format:	Article
Language:	English
Published:	Elsevier 2003-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319327410

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