A negative correlation of thyroid stimulating hormone with anti_mullerian hormone and with luteinizing hormone in polycystic ovary syndrome and/or hypothyroid women

• Main Author: Samal Hakeem Kareem AL-Jaff
• Format: Article
• Language: English
• Published: SpringerOpen 2018-12-01
• Series: Middle East Fertility Society Journal
• Online Access: http://www.sciencedirect.com/science/article/pii/S1110569018300566

Background: Using anti_mullerian hormone (AMH) for Polycystic Ovary Syndrome diagnosis is not always constant. Thyroid dysfunction may effect on AMH levels. Objective: This study was designed to detect: (1) To detect the level of Anti_mullerian hormone and Luteinizing Hormone in hypothyroid patients and in patients who have both diseases (Polycystic Ovary Syndrome and Hypothyroid). (2) A possible correlation between Anti_mullerian hormone and Thyroid Stimulating Hormone and between Luteinizing Hormone and Thyroid Stimulating Hormone. Patients and methods: Eighty women were included in this study between (February 2015 to June 2017), which divided to four groups, control group, Polycystic Ovary Syndrome group, Hypothyroid group, and Polycystic Ovary Syndrome + hypothyroidism group, the women age was ranged between (26–40) years. Results: The serum AMH sub normal (P ≤ 0.01) in hypothyroid women. Luteinizing Hormone, Triiodothyronine (T3) and Thyroxine (T4) were higher (P ≤ 0.01) accompanied by low Thyroid Stimulating Hormone in Polycystic Ovary Syndrome patients. Statistical analysis also showed a negative correlation (P ≤ 0.001) between Anti_mullerian hormone and Thyroid Stimulating Hormone and between Thyroid Stimulating Hormone and Luteinizing Hormone except in the healthy control group. Conclusion: (1) Hypothyroidism accompanied by a low Anti_mullerian hormone. (2) Anti_mullerian hormone does not present an accurate picture of the ovaries in Polly Cystic Ovary Syndrome if there were thyroid abnormalities. (3) Suffering from Polly Cystic Ovary Syndrome for long period may cause Goiter when the Luteinizing Hormone level is high. Keywords: Anti_mullerianhormone, Polly cystic ovary syndrome, Hypothyroid, Thyroid stimulating hormone, Luteinizing hormone, Thyroxine and triiodothyronine