Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion

Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion

Through a chemical genetics screen and phospho-proteomics, Ledet and Ruff et al identify substrates of the oncogenic kinase PIM1 in prostate cancer cells. They find that NDRG1 protein is destabilized by PIM1-mediated phosphorylation to reduce its metastasis suppressor function. These findings shed l...

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Main Authors: Russell J. Ledet, Sophie E. Ruff, Yu Wang, Shruti Nayak, Jeffrey A. Schneider, Beatrix Ueberheide, Susan K. Logan, Michael J. Garabedian
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01528-6
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spelling doaj-80eaf72f1a91430f8ee15122bdc18eb32021-01-10T12:41:26ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111210.1038/s42003-020-01528-6Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasionRussell J. Ledet0Sophie E. Ruff1Yu Wang2Shruti Nayak3Jeffrey A. Schneider4Beatrix Ueberheide5Susan K. Logan6Michael J. Garabedian7Departments of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartments of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartments of Biochemistry and Molecular Pharmacology, New York University School of MedicineProteomics Laboratory, New York University School of MedicineDepartments of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartments of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartments of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Urology, New York University School of MedicineThrough a chemical genetics screen and phospho-proteomics, Ledet and Ruff et al identify substrates of the oncogenic kinase PIM1 in prostate cancer cells. They find that NDRG1 protein is destabilized by PIM1-mediated phosphorylation to reduce its metastasis suppressor function. These findings shed light on the role of PIM1 in prostate cancer.https://doi.org/10.1038/s42003-020-01528-6
collection DOAJ
language English
format Article
sources DOAJ
author Russell J. Ledet
Sophie E. Ruff
Yu Wang
Shruti Nayak
Jeffrey A. Schneider
Beatrix Ueberheide
Susan K. Logan
Michael J. Garabedian
spellingShingle Russell J. Ledet
Sophie E. Ruff
Yu Wang
Shruti Nayak
Jeffrey A. Schneider
Beatrix Ueberheide
Susan K. Logan
Michael J. Garabedian
Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion
Communications Biology
author_facet Russell J. Ledet
Sophie E. Ruff
Yu Wang
Shruti Nayak
Jeffrey A. Schneider
Beatrix Ueberheide
Susan K. Logan
Michael J. Garabedian
author_sort Russell J. Ledet
title Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion
title_short Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion
title_full Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion
title_fullStr Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion
title_full_unstemmed Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion
title_sort identification of pim1 substrates reveals a role for ndrg1 phosphorylation in prostate cancer cellular migration and invasion
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description Through a chemical genetics screen and phospho-proteomics, Ledet and Ruff et al identify substrates of the oncogenic kinase PIM1 in prostate cancer cells. They find that NDRG1 protein is destabilized by PIM1-mediated phosphorylation to reduce its metastasis suppressor function. These findings shed light on the role of PIM1 in prostate cancer.
url https://doi.org/10.1038/s42003-020-01528-6
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