Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy

Multiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy

To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film with empty micelles. Then the micelles in liposomal...

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Bibliographic Details
Main Authors: Wenli Zhang, Caibin Li, Ya Jin, Xinyue Liu, Zhiyu Wang, John P. Shaw, Bruce C. Baguley, Zimei Wu, Jianping Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
multiseed liposomes
active loading
micelle gradient
drug retention
efficacy
Online Access:http://dx.doi.org/10.1080/10717544.2018.1440669

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