An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance

An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance

The evolution of therapeutic resistance is a major cause of death for cancer patients. The development of therapy resistance is shaped by the ecological dynamics within the tumor microenvironment and the selective pressure of the host immune system. These selective forces often lead to evolutionary...

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Bibliographic Details
Main Authors: Shengnan Xu, Kathryn E. Ware, Yuantong Ding, So Young Kim, Maya U. Sheth, Sneha Rao, Wesley Chan, Andrew J. Armstrong, William C. Eward, Mohit Kumar Jolly, Jason A. Somarelli
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Journal of Clinical Medicine
Subjects:
evolution
systems biology
autophagy
lung cancer
epithelial–mesenchymal transition
tumor invasiveness
metabolism
Online Access:https://www.mdpi.com/2077-0383/8/2/205

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