Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.

Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.

Malaria-causing Plasmodium parasites traverse the mosquito midgut cells to establish infection at the basal side of the midgut. This dynamic process is a determinant of mosquito vector competence, yet the kinetics of the parasite migration is not well understood. Here we used transgenic mosquitoes o...

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Main Authors: Gloria Volohonsky, Perrine Paul-Gilloteaux, Jitka Štáfková, Julien Soichot, Jean Salamero, Elena A Levashina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008739
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spelling doaj-80d89236479a48daa92c33851d84e21f2021-04-21T17:16:56ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742020-09-01169e100873910.1371/journal.ppat.1008739Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.Gloria VolohonskyPerrine Paul-GilloteauxJitka ŠtáfkováJulien SoichotJean SalameroElena A LevashinaMalaria-causing Plasmodium parasites traverse the mosquito midgut cells to establish infection at the basal side of the midgut. This dynamic process is a determinant of mosquito vector competence, yet the kinetics of the parasite migration is not well understood. Here we used transgenic mosquitoes of two Anopheles species and a Plasmodium berghei fluorescence reporter line to track parasite passage through the mosquito tissues at high spatial resolution. We provide new quantitative insight into malaria parasite invasion in African and Indian Anopheles species and propose that the mosquito complement-like system contributes to the species-specific dynamics of Plasmodium invasion.https://doi.org/10.1371/journal.ppat.1008739
collection DOAJ
language English
format Article
sources DOAJ
author Gloria Volohonsky
Perrine Paul-Gilloteaux
Jitka Štáfková
Julien Soichot
Jean Salamero
Elena A Levashina
spellingShingle Gloria Volohonsky
Perrine Paul-Gilloteaux
Jitka Štáfková
Julien Soichot
Jean Salamero
Elena A Levashina
Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.
PLoS Pathogens
author_facet Gloria Volohonsky
Perrine Paul-Gilloteaux
Jitka Štáfková
Julien Soichot
Jean Salamero
Elena A Levashina
author_sort Gloria Volohonsky
title Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.
title_short Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.
title_full Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.
title_fullStr Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.
title_full_unstemmed Kinetics of Plasmodium midgut invasion in Anopheles mosquitoes.
title_sort kinetics of plasmodium midgut invasion in anopheles mosquitoes.
publisher Public Library of Science (PLoS)
series PLoS Pathogens
issn 1553-7366
1553-7374
publishDate 2020-09-01
description Malaria-causing Plasmodium parasites traverse the mosquito midgut cells to establish infection at the basal side of the midgut. This dynamic process is a determinant of mosquito vector competence, yet the kinetics of the parasite migration is not well understood. Here we used transgenic mosquitoes of two Anopheles species and a Plasmodium berghei fluorescence reporter line to track parasite passage through the mosquito tissues at high spatial resolution. We provide new quantitative insight into malaria parasite invasion in African and Indian Anopheles species and propose that the mosquito complement-like system contributes to the species-specific dynamics of Plasmodium invasion.
url https://doi.org/10.1371/journal.ppat.1008739
work_keys_str_mv AT gloriavolohonsky kineticsofplasmodiummidgutinvasioninanophelesmosquitoes
AT perrinepaulgilloteaux kineticsofplasmodiummidgutinvasioninanophelesmosquitoes
AT jitkastafkova kineticsofplasmodiummidgutinvasioninanophelesmosquitoes
AT juliensoichot kineticsofplasmodiummidgutinvasioninanophelesmosquitoes
AT jeansalamero kineticsofplasmodiummidgutinvasioninanophelesmosquitoes
AT elenaalevashina kineticsofplasmodiummidgutinvasioninanophelesmosquitoes
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