The Antiproliferative Effect of Cyclodipeptides from Pseudomonas aeruginosa PAO1 on HeLa Cells Involves Inhibition of Phosphorylation of Akt and S6k Kinases

The Antiproliferative Effect of Cyclodipeptides from Pseudomonas aeruginosa PAO1 on HeLa Cells Involves Inhibition of Phosphorylation of Akt and S6k Kinases

Pseudomonas aeruginosa PAO1, a potential pathogen of plants and animals, produces the cyclodipeptides cyclo(l-Pro-l-Tyr), cyclo(l-Pro-l-Phe), and cyclo(l-Pro-l-Val) (PAO1-CDPs), whose effects have been implicated in inhibition of human tumor cell line proliferation. Our purpose was to investigate in...

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Bibliographic Details
Main Authors: Laura Hernández-Padilla, Dolores Vázquez-Rivera, Luis A. Sánchez-Briones, Alma L. Díaz-Pérez, José Moreno-Rodríguez, Mario A. Moreno-Eutimio, Victor Meza-Carmen, Homero Reyes-De la Cruz, Jesús Campos-García
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
biomolecule
cyclodipeptides
antitumoral activity
cell proliferation
apoptosis
Akt–S6k signaling
HeLa
Online Access:http://www.mdpi.com/1420-3049/22/6/1024

Internet

http://www.mdpi.com/1420-3049/22/6/1024

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