Gonadotropin-Releasing Hormone Receptors in Prostate Cancer: Molecular Aspects and Biological Functions

Gonadotropin-Releasing Hormone Receptors in Prostate Cancer: Molecular Aspects and Biological Functions

Pituitary Gonadotropin-Releasing Hormone receptors (GnRH-R) mediate the activity of the hypothalamic decapeptide GnRH, thus playing a key role in the regulation of the reproductive axis. Early-stage prostate cancer (PCa) is dependent on serum androgen levels, and androgen-deprivation therapy (ADT),...

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Bibliographic Details
Main Authors: Fabrizio Fontana, Monica Marzagalli, Marina Montagnani Marelli, Michela Raimondi, Roberta M. Moretti, Patrizia Limonta
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
castration-resistant prostate cancer (CRPC)
GnRH receptors (GnRH-R)
antiproliferative/proapoptotic activity
GnRH agonists
GnRH antagonists
cytotoxic GnRH-based bioconjugates
Online Access:https://www.mdpi.com/1422-0067/21/24/9511

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