Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome

To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER.All cases were diagnosed as non-convulsive S...

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Bibliographic Details
Main Authors: Estevo Santamarina, Alicia Alpuente, Olga Maisterra, María Sueiras, Silvana Sarria, Lorena Guzman, Laura Abraira, Javier Salas-Puig, Manuel Toledo
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Epilepsy and Behavior Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213323218301695
Description
Summary:To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER.All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI.In our patients, PER was an effective option in SE associated with MELAS syndrome. Keywords: Status epilepticus, Perampanel, MELAS
ISSN:2213-3232

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