Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons

Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN). Spasticity appears in ALS patients leading to further disabling consequences. Loss of the inhibitory tone induced by downregu...

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Bibliographic Details
Main Authors: Laura eModol, Renzo eMancuso, Albert eAle, Isaac eFrancos Quijorna, Xavier eNavarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Spasticity
KCC2 transporter
motoneuron disease
SOD1G93A mice
hypereflexia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00007/full

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